The Safest and Richest Midsize Midwest Cities in 2026

Having moved countless times—often on short notice—I know how much peace of mind matters when choosing your next home. If you’re considering a move to the Midwest, you’ll be glad to know that there are eight midsize cities in the region where both safety and prosperity go hand in hand. Each boasts a median income over $100,000, home values ranging from $376,000 to $610,000, and living costs between $48,790 and $67,194. Even better, these cities have low crime rates and populations between 75,000 and 500,000—meaning you won’t have to compromise on community or comfort. As someone who helps families and individuals navigate big transitions, I always look for places that offer security, opportunity, and a true sense of belonging.